And we never open it because something quite terrible is behind it...?

Description: Teenage friends find their lives upended by the wonders and horrors of puberty.

Cast:
Nick Birch: Nick Kroll
Andrew Glouberman: John Mulaney
Jessi Glaser: Jessi Klein
Jay Bilzerian: Jason Mantzoukas
Elliot Birch: Fred Armisen
Connie the Hormone Monstress: Maya Rudolph
Ghost of Duke Ellington: Jordan Peele
Missy Foreman-Greenwald: Ayo Edebiri
Matthew MacDell: Andrew Rannells
Caleb: Joe Wengert
Marty Glouberman: Richard Kind
Barbara Glouberman: Paula Pell
Judd Birch: Jon Daly
DeVon: Jak Knight
Devin LeSeven: June Diane Raphael
Greg Glaser: Seth Morris
Shannon Glaser: Jessica Chaffin
Brad: Gil Ozeri
Lars: Neil Casey
Mona: Thandiwe Newton
Monica Foreman-Greenwald: Chelsea Peretti
Backup singer: Mark Rivers
Gina Alvarez: Gina Rodriguez
Ali: Ali Wong
Leah Birch: Chloe Fineman
Walter: Brandon Kyle Goodman
Tito the Anxiety Mosquito: Maria Bamford
Shame Wizard: David Thewlis
Jenna Bilzerian: Heather Lawless
Val Bilzerian: Mark Duplass
Aiden: Zachary Quinto
Nathan Fillion: Nathan Fillion
Kurt Bilzerian: Paul Scheer
Milk: Emily Altman
Depression Kitty: Jean Smart
Samira: Fran Gillespie
Elijah: Brian Tyree Henry
DNA Expert: Ashley London
Kimberly MacDell: Julie White
Sonya: Pamela Adlon
Edward MacDell: Gary Cole
Montel: Cole Escola
Suzette: Natasha Lyonne
Ms. Benitez: Rosa Salazar
Seamus MacGregor: Peter Capaldi
Mr. Lizer: Rob Huebel
Bernie Sanders: Kristen Schaal
Cantor Dina Reznick: Michaela Watkins
Charles Lu: Joel Kim Booster
Tyler the Hormone Monster: John Gemberling
Choir Girl: Crissy Guerrero
Pubic Hair #1: Jack McBrayer
Flanny O'Lympic: Chris O'Dowd
Jessi's Vagina: Kristen Wiig
Quinta: Quinta Brunson
Pam: Kristen Bell
Dr. Wendy Engle: Andy Daly
Sorority Girl #1: Mitra Jouhari
Cherry Marashina: Julie Klausner
Pubic Hair #2: Craig Robinson
Michael Angelo: Sterling K. Brown
Gavin: Bobby Cannavale
3 episodes, 2020: Willie Garson
Gratitoad: Zach Galifianakis
Lewis Glouberman: Judd Hirsch
Rochelle: Keke Palmer
Harry: John Oliver
Roland: Alia Shawkat
Seth Goldberg: Seth Rogen
Natalie El-Khoury: Josie Totah
Ghost of Freddie Mercury: Brendan McKian
Lena: Lena Waithe
Jerome: Harvey Fierstein
Skip Glouberman: David Cross
Gustavo: Carlos Alazraqui
Jessi Glaser - singing double: Ileen Goldsmith
Diane Lane: Georgie Kidder
2 episodes, 2019: Chris Redd
Daniel: Zach Woods
Missy's Overalls: Somali Rose
Bobby Berk: Bobby Berk
The Rice Purity Test: Annaleigh Ashford
Fatima: Nasim Pedrad
Karamo Brown: Karamo Brown
Simon Sex: Jemaine Clement
Emmy: Aidy Bryant
Rita St. Swithens: Juliet Mills
Self: Steve-O
Movie Theater Customer: Jon Gabrus
Menopause Banshee: Carol Kane
1 episode, 2019: Jaboukie Young-White
Tan France: Tan France
Andrew's Shit: Paul Giamatti
Misha: Maya Erskine
Dick That Looks Like Hugh Jackman: Hugh Jackman
Dwayne 'The Rock' Johnson: Jess Harnell
Man #3: Jerry Minor
1 episode, 2020: Karan Soni
The Apple Brooch: Jeff Goldblum
Bros 4 Life Member #1: Ed Helms
Duke's mother: Retta
Izzy: Anna Konkle
Bros 4 Life Member #2: Adam Levine
Tallulah Levine: Mae Whitman
Tanya Alvarez: Philip Quinaz
Antoni Porowski: Antoni Porowski
Siamese Twin #2: Piotr Michael
Mrs. Albert: Anna Graves
Ghost of Harriet Tubman: Wanda Sykes
Scallops: Jon Hamm
Auntie Amber: Amber Ruffin
Sgt. Adderall: Rob Riggle
Mr. Keating: Adam Scott
Sorority Girl #2: Kristen Rivers
Bros 4 Life Member #3: Matt Rogers
Gordie: Martin Short
Jonathan Van Ness: Jonathan Van Ness
Jones: Max Silvestri
1 episode, 2022: Devon Walker
Reese's Wertherspoon: Marisa Lark Wallin
Jesus: Tyler the Creator

Written by: Jennifer Flackett, Andrew Goldberg, Nick Kroll

Production: Burbank Animation Studios

Release date: 29 Sep 2017